Since 2012, LabEx ParaFrap (the French Alliance for Parasitology and Health Care) [https://labex-parafrap.fr/en/], consisting of 17 leading research labs across France, has committed to fundamental research and translational applications intending to control major parasitic diseases caused by Plasmodium, Toxoplasma, Trypanosoma, Leishmania, Entamoeba, and Theileria. Within the last 10 years, ParaFrap has offered 4 calls for PhD students and 2 calls for Postdoctoral researchers, as well as 4 editions of the ParaFrap Biannual parasitology meeting. For the 2022 workshop on “New frontiers in host-parasite interactions, from cell to organism” ParaFrap partnered up, as in 2018, with EMBO [https://meetings.embo.org/event/22-host-parasite-interactions]. After the canceled edition of 2020 due to the COVID-19 pandemic, everyone was enthusiastic to attend a fully in-person meeting again. The EMBO workshop took place on the island of Les Embiez, in the south of France, where almost 200 researchers gathered for an exciting and scientifically-rich meeting from the 2nd to the 5th of October 2022 (Figure 1). After meeting at the train station in Marseille, several buses took the participants to Six-Fours-Les-Plages, where a boat carried us to our final destination. A good mix of international junior and senior scientists representing 20 countries profited from high-quality presentations, scientific discussions, and several networking opportunities. During the 4 days, about 40 talks and 100 posters were presented on a wide range of parasites and corresponding vectors. The main sponsors: EMBO journal, LabEx ParaFrap, Boehringer Ingelheim Stiftung, Molecular Microbiology, and eLife, allowed an affordable meeting for students and postdocs. The workshop hosted 1 EMBO young-investigator lecture (Taco Kooij), 13 invited speakers, and 8 keynote speakers. In addition, the generous contribution of the sponsors guaranteed the allocation of 2 talk prizes and 4 poster prizes selected by a jury and the audience (Table 1). This workshop aimed at bringing together researchers to discuss the latest discoveries in parasitology and to promote the development of the scientific community. The different scientific sessions highlighted the recent research on “Host manipulation and avoidance strategies”, “Host Immune reactions and pathogenesis”, “Parasite reservoirs and niches”, “Parasite molecular biology and signaling”, “Parasite cell biology”, “Host-parasite interactions (including vectors)” and “Vaccination and control strategies”. Once again, the power and versatility of single-cell RNA sequencing were demonstrated by several speakers with their work on diverse parasite species including Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum to cite only a few as well as the study of the host immune response. Moreover, we learned how the integration of spatial transcriptomics with single-cell RNA sequencing allows a deeper understanding of cellular and tissue responses to infections, by preserving the spatial distribution of parasites in the infected organs. Multiple talks focused on the characterization of sexual commitment, important for transmission, including Plasmodium, Toxoplasma, and Cryptosporidium revealing the involvement of transcription factors and epigenetic switches. Such work will be key to impairing transmission and therefore preventing infection of these various pathogens. Over the past few years, expansion microscopy has gained popularity in several branches of biology, and the parasitology community is no exception. The technique has allowed fine dissection of morphological details of various parasites, including the basal and apical pole of Toxoplasma gondii, the flagellar pocket collar of Trypanosoma brucei, or the secretory organelles of Cryptosporidium parvum. The development of vaccines was also an important part of the meeting as no vaccine against parasites was generated until the recent world's first malaria vaccine RTS,S, for use in children. We additionally heard about PRIMVAC, a placental malaria vaccine aiming to prevent severe consequences of Plasmodium infections during pregnancy which is currently undergoing clinical trials. Also, the apparently insurmountable barrier to vaccination due to antigenic variation in trypanosomes can be overcome. In fact, vaccination with a conserved invariant surface protein induced long-lasting protection against Trypanosoma vivax in a murine model. Highly essential but sometimes still elusive molecular mechanisms of proper cell functioning, spanning from organelle dynamics during cell division in apicomplexan parasites, molecular signaling in stage development, to the role of 3D genome architecture, were touched by several talks and posters. Another topic discussed during the meeting was the emergence and spread of drug resistance, a problem not only related to the parasitology field. Discovering how drug resistance arises and deciphering the mode of action of the current treatments can help prevent resistance and improve novel therapeutics. One elegant approach to explore this matter is the Mut-Seq technique, which combines chemical mutagenesis with next-generation sequencing in Leishmania. The workshop did not only focus on parasitology but aimed at raising awareness on working and living in sustainable and environment-friendly conditions. With an eye to the future, this meeting addressed the need to reduce our footprint by becoming more responsible and aware that our actions can have an impact. To trigger the discussion on this subject, several small acts were implemented: the abstract book was not printed but was available online, a poster on this matter was presented, and a table was allocated during the gala dinner to foster the discussion. Tips and ideas can be found at www.mygreenlab.org. As conference swag, all attendees received a handbag made of recycled material, a pot of olive tapenade, and as a local souvenir - sachets of dried Lavender from French Provence. We sincerely acknowledge the participants for sharing their latest findings and creating an inspiring and open community in fighting against parasitic diseases. We all profited from a fantastic location, which enabled us to walk around the island, or run for the more motivated, and to go out for a short swim in a 19°C revitalizing cold water on the scheduled breaks. Every moment outside the conference room transformed into a networking opportunity in a friendly and relaxing environment. This workshop would not have been possible without the great work of Olivier Silvie, Nicolas Blanchard, and Yoann Millerioux, together with the numerous scientific co-organizers. Mark your calendars as the next workshop will take place at the same venue in late 2024 with, we hope, a similar success. Data sharing is not applicable to this article as no new data were created or analyzed in this study.